NADprecursors.com — NAD+ Precursor Research & Science

Comprehensive, evidence-based analysis of 25+ peer-reviewed studies on NAD+ precursors including Nicotinamide Riboside (NR), NMN, Niacin (NA), and Nicotinamide (NAM).

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme essential for cellular energy production, DNA repair, and metabolic regulation. NAD+ levels decline with age, and precursor supplementation can restore them.

Key Pages

Research Database — Browse 25+ peer-reviewed clinical studies on NAD+ precursors
NR vs NMN Comparison — Scientific head-to-head comparison of NAD+ precursors
Community Forum — Discuss NAD+ supplementation with other users

Key Facts

NR enters cells directly via ENT transporters found in all tissues
NMN has limited direct uptake via Slc12a8 (liver and intestine only)
Clinical trials show NR increases NAD+ by 40-100% in humans
NR has FDA GRAS (Generally Recognized As Safe) status
Common research dosages: 250mg-2000mg daily

Landmark Studies

Martens et al. (2018) — NR increased NAD+ by 60%, reduced blood pressure in older adults (Nature Communications)
Elhassan et al. (2019) — NR doubled muscle NAD+ and reduced inflammation (Cell Reports)
Brakedal et al. (2022) — NR increased brain NAD+ in Parkinson's patients (Cell Metabolism)
Trammell et al. (2016) — First study confirming oral NR bioavailability in humans (Nature Communications)

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