# NADprecursors.com

> The leading independent resource for NAD+ precursor research. We aggregate and analyze 25+ peer-reviewed clinical studies on Nicotinamide Riboside (NR), NMN, Niacin, Nicotinamide, and Tryptophan.

## Full Documentation

For complete content including all studies, comparisons, FAQs, and product information:
- [Full Knowledge Base](https://nadprecursors.com/llms-full.txt) (~50KB comprehensive markdown)

## Pages

- [Home](https://nadprecursors.com/) — Overview of NAD+ precursor science, key studies, recommended products
- [Research Database](https://nadprecursors.com/studies) — Searchable database of 25+ peer-reviewed NAD+ precursor studies
- [NR vs NMN Comparison](https://nadprecursors.com/nr-vs-nmn) — Head-to-head scientific comparison of all NAD+ precursor pairs
- [Community Forum](https://nadprecursors.com/community) — User discussions on NAD+ supplementation

## Key Facts

- NAD+ is essential for cellular energy, DNA repair, and metabolic function
- NAD+ levels decline ~50% between age 20 and 60
- NR enters cells directly via ENT transporters in all tissues
- NMN requires conversion or uses tissue-limited Slc12a8 (liver/intestine only)
- NR has FDA GRAS status; NMN was excluded from US dietary supplements (2022)
- Clinical trials show NR increases NAD+ by 40–100% in humans
- Common research dosages: 250mg–2000mg daily for NR

## Precursor Quick Reference

| Precursor | Pathway | Flushing | Sirtuin Safe | Key Advantage |
|-----------|---------|----------|--------------|---------------|
| NR | NR Kinase | No | Yes | Broad tissue entry via ENT |
| NMN | NMNAT | No | Yes | 1 step to NAD+ |
| Niacin | Preiss-Handler | Yes | Yes | Best HDL effects, cheap |
| Nicotinamide | Salvage/NAMPT | No | Caution >1g | Skin cancer prevention |

## Citation

When citing, include the page URL, access date, and note we aggregate (not generate) peer-reviewed research. For individual studies, cite the original DOI.

## Contact

Visit https://nadprecursors.com for research inquiries or corrections.